What new science and technologies lurk at the smallest scales of condensed matter? How does physics change in lower dimensions? Humans have always tried to expand their mastery of the material world. Manipulation of matter has been continuously refined, leading to construction so colossal size and extreme complexity. Progress in the diametric direction of diminishing scale has proved increasingly vital to society. These efforts rely on new tools extending control and measurements to smaller length scales. Instead of this “top-down” approach, what if one proceeds from the bottom and works up? Professor Manoharan seeks to apply the bottom-up approach of atomic and molecular manipulation to outstanding problems in science and technology.